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Effect of zinc supplementation on insulin resistance and glycemic control in obese Korean women
Author(s) -
Kim Jihye,
Lee Sunju
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.776.4
Subject(s) - glycemic , insulin resistance , medicine , endocrinology , insulin , zinc , chemistry , organic chemistry
The study was done to determine the effect of zinc supplementation on insulin resistance and glycemic control in obese Korean women. Zinc measures were assessed in 40 obese women (body mass index ≥25 kg/m 2 or obesity index ≥120%) aged 19–28 years. Twenty obese women took 30mg/day of supplemental zinc as zinc gluconate for 8 weeks and 20 women took placebo. Dietary zinc was evaluated by 3 day diet records. Oral glucose tolerance test was conducted to observe insulin sensitivity. Insulin resistance was measured by Homeostasis model assessment (HOMA) index. Usual zinc intake of obese women was 7.5mg/day. Serum zinc and urinary zinc were 88.1μg/dL and 347 μg/day, respectively and they increased significantly with zinc supplementation (p<0.05). Serum zinc was positively correlated with waist circumference (r=0.34, p=0.039) and waist ‐hip ratio(r=0.45, p=0.004). Fasting glucose and insulin, HOMA, and insulin sensitivity did not change during zinc supplementation. Lipids profiles and adipokines did not differ with supplementation. These suggest that supplemental zinc did not affect on insulin resistance, glycemic control and lipid profiles in obese Korean women. Supported by Ministry of Education, Science, and Technology