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Association of LIPA polymorphisms with obesity‐related metabolic complications
Author(s) -
Guenard Frederic,
Bouchard Luigi,
Tchernof Andre,
Deshaies Yves,
Marceau Simon,
Biron Simon,
Lescelleur Odette,
Biertho Laurent,
Vohl MarieClaude
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.775.5
Mutations in the lipase A, lysosomal acid, cholesterol esterase ( LIPA ) gene can result in Wolman disease and cholesteryl ester storage disease. We previously reported that the LIPA gene was overexpressed in visceral adipose tissue of nondiabetic severely obese men with the metabolic syndrome defined using the NCEP‐ATPIII criteria. Objective We undertook a study to identify LIPA polymorphisms and to test associations between LIPA SNPs and obesity‐related metabolic complications. Methods Direct sequencing was first conducted in 25 subjects to identify polymorphisms and to select tagging SNPs (tSNPs). A two‐stage, case‐control design was applied to a total of 621 obese subjects to test association of tSNPs with obesity‐related metabolic complications (blood pressure, plasma lipids, insulin and glucose levels). Logistic regressions were used to compute the odds ratios (OR) when chi‐square tests reached the significance level in both stages. Results Heterozygotes for rs2071509 were at higher risk to have higher systolic blood pressure (OR = 1.89; P = 0.032). Other tSNPs examined were not related to the obesity‐related risk factors under study. Conclusion These results suggest a link between LIPA polymorphism and blood pressure in severely obese patients. Funding: CIHR