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Efficacy of Two Algae Formulations on Lipid Metabolism, Inflammation, Oxidative Stress Status and Disease Severity in Psoriasis Patients
Author(s) -
Allemekinders Johanna Jacoba,
Chan YenMing,
Robinson Kimberley,
Jones Peter JH
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.773.5
Subject(s) - oxidative stress , psoriasis , inflammation , lipid metabolism , disease , oxidative metabolism , medicine , algae , metabolism , biology , immunology , botany
Consumption of bioactives found in algae can potentially regulate abnormal lipid metabolism and inflammation homeostasis, which are underlying health issues in psoriasis patients. Our objective was to examine the efficacy of a marine algae concentrate (UMAC) and golden brown algae (GBA) supplementation in psoriatic patients. In a double‐blinded, controlled‐diet, cross‐over clinical trial, eighteen subjects randomly received beverages with UMAC, GBA or placebo (90 mg/d) for 29d separated by 4‐wk washout periods. Total cholesterol (TC) and LDL‐C levels decreased following UMAC ( P =0.004 and P= 0.03 for TC and LDL‐C, respectively), GBA ( P= 0.001; P =0.004) and control ( P =0.01; P =0.04) diets. GBA lowered endpoint HDL‐C levels compared to UMAC and control ( P <0.05), however, endpoint LDL‐C/HDL‐C ratios remained unaffected ( P =0.41) across groups. Algae treatments did not alter markers of inflammatory and oxidative stress status. No changes in Psoriasis Area and Severity Index (PASI) scores were observed, yet UMAC and GBA consumption lowered ( P =0.05) endpoint Dermatology Life Quality Index (DLQI) scores, compared to control. Furthermore, GBA lowered DLQI scores at endpoint, compared to baseline ( P <0.05). Overall, supplementation with algae, particularly GBA, can improve health‐related quality of life in psoriasis patients and might modify blood lipid profiles. Supported by Canadian Pacific Algae Inc. Grant Funding Source : Canadian Pacific Algae Inc.