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Effects of Korean Red Ginseng Extract for the Treatment of Atopic Dermatitis‐like Skin Lesions in Mice
Author(s) -
Sohn EunHwa,
Kang NamSung,
Jung DaHye,
Jang KiHyo,
Kim SunYoung
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.772.8
Atopic dermatitis (AD) is an allergic and chronic inflammatory skin disease characterized by pruritic chronic eczema, mechanical injury to the skin by scratching. Korean red ginseng (RG) has been known to have diverse biological activities, but the molecular effects of RG on allergic diseases like AD has not been clarified yet. Examination performed in this study was to evaluate whether RG application could exert inhibitory effects on DNCB (1‐chloro‐2,4‐dinitrobenzene)‐induced AD mouse model. DNCB was topically applied on the dorsal surface of the Balb/c mice as an inducer of AD‐like skin lesion. We observed the scratching behavior and examined the level of serum IgE and IL‐4, IL‐10 in splenocytes compared with dexamethasone. We also evaluated the DNCB‐induced MAPKs, nuclear factor (NF)‐κB, and Ikaros activities after RG treatment using RT‐PCR, western blotting, and ELISA. Our data showed that topical application of RG significantly improved the degree of AD‐like skin lesion and scratching behaviors. RG decreased not only mRNA expression of IL‐4, IL‐10 but also secretion of IL‐4 and serum IgE in mouse. In addition, RG treatment decreased DNCB‐induced MAPKs activity and subsequent Ikaros translocation irrespective of NF‐κB. We herein suggest that RG could be used as a therapeutic or an effective adjuvant agent for the treatment of AD.