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Improved Bioavailability and Anti‐Adipogenic Property of Water‐Soluble Curcumin Conjugates
Author(s) -
Kim KeeHong,
Kim Choon Young,
Bordenave Nicolas,
Ferruzzi Mario G,
Safavy Ahmad
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.771.8
Despite curcumin's (CCM) safe and health benefits, its poor water solubility and bioavailability limit its application to clinical uses. CCM conjugated with polyethylene glycol (PEG) has been developed to improve water solubility of the natural form of CCM with its effective regulation of the growth of some human cancer cell lines. Here, we determined the cellular uptake kinetics of the natural form of CCM and PEG‐CCM, and their effects on cellular viability and differentiation of 3T3‐L1 preadipocytes. CCM and CCM‐PEG were found to be differently absorbed in 3T3‐L1 preadipocytes and adipocytes possibly through a passive diffusion for CCM and a facilitated diffusion for CCM‐PEG. The improved water solubility of CCM‐PEG was correlated with its increased cellular retention in 3T3‐L1 preadipocytes. Consequently, CCM‐PEG treatment resulted in sensitization of preadipocytes to CCM‐induced cell toxicity, and improvement of anti‐adipogenic property in vitro. These results suggest that pegylated CCM enhances the bioavailability of CCM and its biological function in preadipocytes, as compared to the natural form of CCM.