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Dairy Calcium Intake and Relationship to Bone Mineral Density BMD, Bone Mineral Content BMC and Leptin in Obese Post‐Menopausal Women
Author(s) -
Nakhoul Raeida,
Beeson Lawrence,
Fakhrawi Dina,
Darnell Alen,
Shulz Eloy,
CorderoMacIntyre Zaida
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.770.10
It has been reported that as women lose weight they may also lose bone mineral density (BMD) (g/cm2) and bone mineral content(BMC)(g). Objective This study placed 56 obese postmenopausal women on a dairy calcium diet to reduce body weight while maintaining BMC and BMD during a 3 month intervention. Methods The diet restricted subjects to a 1,400 kcal/d who were randomized to low calcium ~800 mg/d or high calcium ~1400 mg/d. At baseline subjects were 55.61±8.19 yrs.; weight 86.87±7.25 (kg); BMI of 32.55±6.12 (kg/m2); BMC 58.83±12.88 (g); BMD 1.05± .16 (g/cm2); and leptin 30.16±10.12 n/ml. Differences after 3 months in weight, BMI, leptin, BMD and BMC were analyzed. Correlations were calculated between Leptin with BMD (g/cm2) and BMC (g) before and after intervention. Results After the intervention there was a reduction in weight of −1.17±2.59 (kg), 95% CI:(−2.43, −1.02) (p ≤ .001); BMI: −.720±1.01, 95% CI:(−.995, −.444) (p ≤.001); leptin: −1.88±6.91, 95% CI:(−3.73, −.032) (p‐value=0.045). The average change in BMC: .016±1.38, 95% CI of (−.372, .404) (p=.935). BMD: .001±.020, 95% CI of (−.005, .007) (p=.738). Leptin was not correlated with BMD and BMC; .104 (p=.468) and .070 (p=.625) respectively. Conclusion After the intervention there was significant reduction in weight, BMI, and leptin and no significant change in BMC and BMD. There was no correlation between leptin, BMC and BMD. Grant Funding Source : NIH# 5P20MD001632