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Molecular imaging of chemistry in the brain
Author(s) -
Chang Christopher J
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.73.1
The brain requires the body's highest concentrations of metals owing to its high oxygen demand, but misregulation of metal pools and redox balance is connected to oxidative stress and damage cascades that occur with aging and age‐related neurodegenerative diseases. We have initiated a broad‐based program to study the complex roles of metal and redox biology in brain health, aging, and disease by creating new fluorescent and MRI indicators to track metals and reactive oxygen species in living cells, tissue, and organisms. The design, synthesis, and evaluation of our most recent platforms and their use in molecular imaging will be presented.