Premium
Evaluation Of Toxicity And Antioxidant Potency Of Viscum Album L. Aqueous Leaf Extract
Author(s) -
Nwoke Stella C,
Magbagbeola Olubunmi A,
Ebuehi Albert O,
Iwalokun Bamidele A,
Olowookere Omolara A
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.722.13
The hepatoprotective effect of aqueous extract of the leaf of Viscum album against Fenton solution‐induced oxidative damage was investigated in albino mice. 30 Albino mice were divided into five experimental groups, group 1 and 2 serve as positive and negative control respectively, the animals in group 1 were given Phosphate Buffer Saline (PBS), those in group 2 were given Fenton solution (2ml/day) throughout the study. While mice in groups 3, 4 and 5 were given Fenton's solution orally (0.2ml/day) for three days to induce oxidative stress and aqueous extract of Viscum album L was administered (2ml/day) in different concentrations, 62.5, 125 and 250mg/kg body weight to the three groups respectively. The investigation showed that there was a significant increase (P<0.05) in the antioxidant potency as the dose of administered Viscum album extract increased. However, the concentration of liver marker enzymes (AST and ALT) increased as the concentration of extract administered increased and tissue histopathology result of organs such as liver, kidney and heart revealed that the extract is significantly toxic at concentrations of 125 and 250mg/kg body weight. Results show that Viscum album leaf extract could act as an antioxidant against Fenton solution‐induced oxidative damage.