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The PON1 is a susceptibility gene for acquiring metabolic syndrome
Author(s) -
AlRasheed Maha M,
AlNajai Mohammed,
Villiga Mary Grace,
Muiya Paul,
Andres Editha,
Alshahid Maie,
Dzimiri Nduna
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.717.1
Metabolic syndrome (MS) describes a cluster of risk factors for atherosclerotic disease and type 2 diabetes mellitus comprising obesity, insulin resistance, hypertension and dyslipidemia. The role of the PON1 gene in these conditions has not been fully studied yet. In a preliminary genome‐wide linkage study of early onset CAD involving two families (22 individuals) with predominant familial hypercholesterolemia, we identified several loci, among others, on chromosome 7 which harbours the PON1 gene using the Affymetrix Gene Chip 250 sty1 mapping array. We then pursued a population‐based association study for 5 PON1 SNPs ( rs854560 , rs662, rs854552 , rs3917577 and rs3735590) with MS risk factors in 3048 individuals (1013 HL cases versus 2035 controls) using the Applied Biosystems real‐time PCR procedure. The rs3735590 [Odds ratio(95% Confidence Interval = 1.23(1.08–1.40); p=0.002) was strongly implicated, while the rs662 [1.10(0.99–1.20); p=0.071] rs854552 and rs854552 [1.10(1.00–1.22); p=0.061) showed a causative borderline association with obesity. Besides, the rs662 [1.12(1.02–1.22); p=0.018] was also associated with hyperlipidemia, while the rs854560 (p=0.031) was linked with low high density lipoprotein levels. Thus, our results indicate that PON1 polymorphism is associated with harbouring of combinations of MS risk factors, therefore predisposing individuals to acquiring this condition.