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High‐fat diet repressed p21 gene while induced p16 gene and nonalcoholic fatty liver disease in male rats
Author(s) -
Zhang Xiyuan,
Pan YuanXiang
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.698.18
Background Nonalcoholic fatty liver disease (NAFLD) is among the most common causes of chronic liver disease in the western world. It has been reported that high‐fat diet is one of the risk factors but the exact cause of NAFLD is unknown. This study tested the hypothesis that cellular senescence is associated with NAFLD in adult male rats. Material and methods Sprague Dawley rats were fed a high‐fat (HF) diet or a control (C) diet for 9 weeks after weaning. At 12 weeks of age, liver samples of male rats were collected to investigate the key genes and liver physiological status. Results Histology data showed that NAFLD was observed in HF group. mRNA level of aging and senescence marker, p16 (CDK4), was increased significantly (p<0.01) in HF group when compared to C group. Reversely, mRNA expression of another inhibitor of cyclin dependent kinase, p21 (Cip1), was decreased significantly (p<0.01) in HF group. Conclusions We conclude that HF diet induced cellular senescence markers are associated with the undergoing NAFLD.