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Comparison of DEXA and QMR for assessing fat and lean body mass in adult rats
Author(s) -
Miller Colette N,
Kauffman Tricia G,
Cooney Paula T,
Ramseur Keshia R,
Brown Lynda M
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.687.6
Subject(s) - lean body mass , subcutaneous fat , lean tissue , dual energy , body weight , zoology , fat mass , medicine , endocrinology , biology , adipose tissue , bone mineral , osteoporosis
There are several techniques used to measure body composition in experimental models including dual energy x‐ray absorptiometry (DEXA) and quantitative magnetic resonance (QMR). DEXA/QMR data have been compared in mice, but have not been compared previously in rats. The goal of this study was to compare DEXA and QMR data in rats. We used rats that varied by sex, diet, and age, in samples containing subcutaneous (pelt) or visceral fat (carcass). Data means were compared using scatter plots. DEXA/QMR data did not agree sufficiently in carcass or pelt FM or in pelt LBM. The variation observed within these groups suggests that DEXA and QMR measurements are not comparable. Carcass LBM in young rats did yield comparable data once the data for middle‐aged rats was removed. The variation in our data may result from different direct and indirect measures that DEXA and QMR technologies use to quantify FM and LBM. We found that QMR overestimated body mass in our middle‐aged rats, and this increased the variation between methods. However DEXA and QMR did not yield the same estimates of FM or LBM for the majority of our samples. This research was supported by USDA ARS NC06871 & a UNCG New Faculty Grant.