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Evaluation of Lactate Dehydrogenase Activities in Adult Nigerians Affected with Hematological Malignancies
Author(s) -
Akinlolu Adelaja Abdulazeez,
Salau Bamidele,
Akingbola Titi
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.686.8
Lactate dehydrogenase (LDH; EC 1.1.1.27 ) is an enzyme ubiquitously found in body tissues including the heart and red blood cells. LDH converts lactate in aerobic tissues into pyruvate thus aiding the production of cellular energy. This study tested the hypothesis that LDH activity is significantly increased in individuals affected with hematological malignancies when compared to healthy subjects. Total LDH activities were studied using RANDOX LDH kit (Randox laboratories limited; United Kingdom) in the sera of 22 adult Nigerians affected with hematological malignancies: 6 Chronic Myeloid Leukemia patients, 6 Chronic Lymphocytic Leukemia patients, 4 Multiple Myeloma patients, 4 Non‐Hodgkin's Lymphoma patients, 2 Hodgkin's Lymphoma patients; and 10 control apparently healthy adult Nigerian subjects. International standard ethical procedures were followed in this study. The LDH activity values were significantly increased (P < 0.05) in all individuals affected with hematological malignancies when compared to control subjects. Increased LDH activities have been established in diseased conditions including cancers due to leakage of LDH isoenzymes from diseased organs or bone marrow cells breakdown in marked defective erythropoiesis. This study observed that evaluation of LDH activities may have potential diagnostic and prognostic values in individuals affected with hematological malignancies. Grant Funding Source : UNIVERSITY OF ILORIN, NIGERIA