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Effect of various doses of forced swim‐stress on thermal threshold in C57Bl/6J mice
Author(s) -
Schilling Jan Mirko,
Kellerhals Sarah E.,
Clark Sarah V.,
Guryev Igor,
Chan Angela S.,
Kuo Catherine,
Niesman Ingrid,
Patel Hemal H.,
MoellerBertram Tobias
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.677.3
Stress and pain are linked in many medical and psychiatric disorders. Delayed hyperalgesia was produced by 3 days of forced swim stress (FSS) in rats. In contrast, exercise swim stress has been shown to reduce pain behavior in mice. To investigate if in‐ or decrease in pain behavior is mediated by different amounts of stress, we exposed C57Bl/6J mice to various amounts of FSS and then measured the paw withdrawal latency using a modified Hargreaves' device (HD). Mice were tested on the HD before and after various durations (3, 4 or 5 days) of FSS at random time points throughout the day. Baseline measurements were performed to control for a possible learning effect on the HD. We showed no significant differences in paw withdrawal latencies for any FSS duration when compared to control or sham animals. However, we detected a trend towards significance for a learning effect in our baseline group. Overall our results showed no change in pain behavior in response to FSS in mice. Limitations may be small group size and further evaluation is clearly needed.