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Evaluation of hyperalgesia and muscle perimeter in male Wistar rats after nociceptive stimulation in neonatal period
Author(s) -
Cássia do Carmo Elisabete,
Machado Nathalia Leilane Berto,
Sanada Luciana Sayuri,
Fazan Valéria Paula Sassoli
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.677.2
The aim of this study was to evaluate nociception and muscle perimeter of the hind paw in male Wistar rats, exposed to painful stimulation after birth. Male Wistar rats with 90 days of life were separated in 2 groups: pain group (n=4) and control group (n=4). The pain group was stimulated with a needle on the right paw, twice a day for 15 days. The control group was stimulated with a cotton swab on the right paw, twice a day for 15 days. Assessment of nociception on the hind paw, right and left sides, was performed using Von Frey monofilaments and a calibrated forceps. The muscle was measured with a caliper rule associated with tape. Differences were tested between right and left paws and between groups and were considered significant when p less than 0.05. Our results showed that the pain group had lower score when we analyzed the calibrated forceps, which indicated a possible hyperalgesia. Despite no significant differences in muscle perimeter of the hind paws, the values of the pain group were lower compared to the control group. Our data suggest that the nociceptive stimulation on neonatal period can influence the motor development and the muscle perimeter.