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The effect of curcumin in transforming growth factorβ1‐induced rat lung fibrosis
Author(s) -
Cui Ye,
Robertson Jennifer,
Maharaj Shyam,
Niu Jianzhao,
Wang Jifeng,
Kolb Martin,
Gauldie Jack
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.658.6
Aim We aim to test the effect of curcumin in lung fibrosis induced by adenoviral vector delivery of active transforming growth factor (TGF) β1 (AdTGFβ1). Methods Female Sprague Dawley rats were administered AdTGFβ1 via endotracheal intubation. Rats received daily intraperitoneal (IP) injection or oral administration of curcumin. The effects of curcumin were determined 21 days after virus administration. Results AdTGFβ1 induced severe distortion of lung structure and progressive formation of fibrous areas associated with increased lung compliance compared with the naive group. The pathologic changes in rat lung induced by TGFβ1 gene transfer were not significantly modified by either oral administration or IP injection of curcumin, nor was the increased lung compliance significantly modified. Conclusion In previous published studies, curcumin was administrated during an early phase of bleomycin‐induced experimental fibrosis as a preventative treatment. In our study, we show that neither IP injection nor oral administration of curcumin attenuates progressive lung fibrosis induced by TGFβ1 and indicates that the therapeutic option for curcumin is most effective and may be confined to inflammation that subsequently triggers fibrosis. This work was supported by the Canadian Institute for Health Research (CIHR) and by the 111 project (B07007).