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Chronic exposure of mice to genistein: sex‐dependent effects
Author(s) -
AlNakkash Layla,
Martin Joshua,
Hamrick Christine,
Petty David,
Lynch Shaina,
Lucy Dana,
Batia Lyn,
Peterson Amity,
Rubin Leona,
Broderick Tom L.
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.657.13
Intake of soy may have beneficial cardiovascular health effects, however, the effects of chronic dietary exposure to genistein and an understanding of the underlying mechanism(s) of action of genistein remain vague. We aimed to examine the effects of a 1 month exposure to a genistein‐containing diet (600 mg/kg, 600G) and a genistein‐free diet (0 mg/kg, 0G) on cardiovascular parameters in C57B1/6J male and female mice. In males 600G increased serum levels of insulin (2.9±0.5 ng/dL, n=6), compared to 0G controls (1.8±0.4 ng/dL, n=6, P<0.05) and decreased glucose (177.5±15.9 mg/dL, n=6), compared to 0G controls (242.4±22.5mg/dL, P<0.05). No effects in females. In males, 600G decreased body weight (by ~2.7 g, n=6, P<0.05), with no change in females. In females, 600G (n=11) decreased systolic blood pressure (107.1±3.5 mmHg), pulse pressure (27.7±1.6 mmHg) and cardiac work (18.9±1.2 mmHg beats/min), compared to 0G (115.9±1.7 mmHg, 33.41±1.9 mmHg and 22.78±1.61 mmHg beats/min respectively, n=15, P<0.05). Aortic contractility was increased with 600G in both males and female aorta (P<0.05). These data suggest that a one month diet with 600G has different outcomes on cardiovascular parameters in both males and females. Josh Martin was supported by the Midwestern University Summer Fellowship Program. Layla Al‐Nakkash was supported by NIH (1R15DK071625‐01A2).