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Streptozotocin‐induced activation of group II metabotropic glutamate receptors in the dorsal motor nucleus of the vagus
Author(s) -
Babic Tanja,
Travagli R. Alberto,
Browning Kirsteen
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.648.5
Inhibitory synaptic inputs within the brainstem play an important role in the regulation of pancreatic secretion. Recent work suggests that GABAergic inputs to pancreas‐projecting DMV neurons are regulated by metabotropic glutamate receptors (mGluR). This study aimed to investigate whether mGluR on pancreatic vagal circuits are re‐organized following streptozotocin (STZ) treatment. Whole cell patch clamp recordings were made from pancreas‐projecting DMV neurons from control and STZ‐treated rats. The group II mGluR agonist, APDC (100μM) decreased the frequency of spontaneous inhibitory postsynaptic currents (sIPSCs) in control (42±9% in 3/5 neurons) and STZ treated rats (19±9% in 4/4 neurons). In contrast, the group II mGluR antagonist, EGLU (200μM) increased sIPSC frequency (148 ± 39%; 3/8 neurons) only after STZ treatment These results show that group II mGluR are tonically active following STZ treatment. This suggests that pancreatic vagal neurocircuits are re‐organized following STZ‐induced hyperglycemia and that this remodeling may underlie changes in vagal efferent output controlling visceral functions. Supported by: NIH DK078364 to KNB