Premium
Exercise Training Restores Cardiac and Peripheral Sympathetic Activity and Baroreflex Sensitivity after Acute Myocardial Infarction
Author(s) -
Martinez Daniel G,
ToschiDias Edgar,
Nicolau Jose C,
Lage Rony,
Trombetta Ivani C,
Matos Luciana,
Alves Maria Janieire N,
Silva Valdo Dias da,
Negrao Carlos E,
Rondon Maria Urbana P B
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.647.15
We hypothesized that exercise training (ET) would improve the cardiac and peripheral sympathetic activity and baroreflex sensitivity (BRS) in patients with acute myocardial infarction (MI). Were studied 28 patients with MI (35–64 years) were divided in two groups: Exercise‐trained (MI‐ET, n=14) and untrained (MI‐U, n=14). A normal control group (NC) was also studied (n =17). ET consisted of three 60 min bicycle exercise sessions/wk during six months. Muscle sympathetic nerve activity (MSNA) was evaluated by microneurography, blood pressure by finapress and heart rate by EKG. BRS was evaluated by α‐index. Low frequency component of systolic arterial pressure (LF‐SAP) variability was assessed by autoregressive spectral analysis. ET decreased MSNA and LF‐SAP (62±4 vs. 40±3 bursts/100HB, P< 0.001 and 5.1±0.6 vs. 2.2±0.5 mmHg2, P=0.02, respectively) and increased BRS (8±2 vs. 17±3 ms/mmHg, P=0.008) in MI‐ET group. These changes were significant that reaches the levels found in the NC group. No significant changes were observed in MSNA, LF‐SAP and BRS in the MI‐U group. ET decreases cardiac and peripheral sympathetic activity and increases BRS towards normal levels in patients with MI. These findings highlight the clinical importance of the ET in patients with MI.