Premium
Chronic stress impairs cardiac autonomic modulation in patients with metabolic syndrome
Author(s) -
ToschiDias Edgar,
Trombetta Ivani C,
Dias da Silva Valdo J,
MakiNunes Cristiane,
Alves Maria Janieire N,
Fraga Raffael F,
Angelo Luciana F,
Martinez Daniel G,
Negrao Carlos E,
Rondon Maria Urbana P B
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.647.10
We hypothesized that chronic stress would exacerbate cardiac sympatho‐vagal dysfunction in patients with MetSyn. Twenty‐nine never‐treated patients with MetSyn (ATP‐III) were allocated in two groups according to chronic stress symptoms: patients with chronic stress (MetSyn+Stress, n=13), and patients without chronic stress (MetSyn‐Stress, n=16). Stress was determined by means of quantitative questionnaire. Blood pressure was monitored by Finapres and heart rate by ECG during 10 minutes. Time series of R‐R Interval and systolic blood pressure were analyzed by autoregressive method. Sympatho‐vagal balance was obtained by LF/HF ratio. Spontaneous baroreflex sensitivity (BRS) was evaluated by á‐index. Patients with MetSyn+Stress showed higher LF power (62±4 vs. 48±3 n.u., P=0.02) and lower HF power (28±3 vs. 42±3 n.u., P=0.005) when compared with MetSyn‐Stress. LF/HF balance was significantly higher in MetSyn+Stress when compared with patients with MetSyn‐Stress (2.6±0.3 vs. 1.4±0.2, P=0.01). BRS was significantly decreased in MetSyn+Stress patients when compared with MetSyn‐Stress patients (8.2±1.0 vs. 14.9±2.2 ms/mmHg, P=0.01). Chronic stress exacerbates cardiac sympathetic activation and BRS dysfunction in patients with MetSyn. These findings suggest that chronic stress increases cardiovascular risk in patients with MetSyn.