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INVOLVEMENT OF THE AUTONOMIC NERVOUS SYSTEM IN CARDIOVASCULAR FUNCTION OF MONOSODIUM GLUTAMATE INDUCED OBESE RATS
Author(s) -
KarlenAmarante Marlusa,
Cunha Natália Veronez,
Andrade Ozahyr,
MartinsPinge Marli Cardoso
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.646.7
Data from our laboratory showed that obese animals induced by monosodium glutamate (MSG) are also hypertensive. The literature has shown that the autonomic nervous system is involved in one of the possible causes of hypertension, characterized by sympathetic hyperactivity. The aim of this study was to evaluate the mean arterial pressure (MAP) and heart rate (HR) in control and obese rats before and after ganglionic blocker hexamethonium. Obesity was induced by intradermal MSG (4 mg/g) or hyperosmotic saline (control = CTR) in the first 5 days of life in male Wistar rats. At 90 days old, catheterization was performed in the femoral artery and vein and after 24 hours, MAP and HR baseline values was recorded in non‐anesthetized rats followed by intravenous injection of hexamethonium (25 mg/kg). Obese rats presented hypertension (124 ± 4 mmHg, n = 6) compared with control (111 ± 2 mmHg, n = 7), without changes in basal HR (CTR=372 ± 9 bpm; MSG = 394 ± 16 bpm). Hexamethonium induced a fall in MAP (CTR=−44±4; MSG=−48±3 mmHg), accompanied by tachycardia (CTR=27±9; MSG=24±13 bpm) without differences between groups. Our data showed that the obese animal is hypertensive and ganglionic blockade with hexamethonium canceled the differences between groups. Our data suggest the involvement of autonomic nervous system in the mechanisms generating hypertension in the MSG obese animals.