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Effect of pyridostigmine on both cardiac function and remodeling in heart failure rats
Author(s) -
Lataro Renata Maria,
Silva Carlos Alberto Aguiar,
Prado Cibele M,
Rossi Marcos Antonio,
Fazan Rubens,
Salgado Helio Cesar
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.646.10
We investigated the effects of the reversible acetylcholinesterase inhibitor pyridostigmine (PYR) on sympathovagal balance, cardiac function and cardiac remodeling in heart failure (HF) elicited by large myocardial infarction in Wistar rats. After 4 weeks of treatment with PYR, methyl atropine and propranolol were used to evaluate the sympathovagal balance. In HF rats PYR increased vagal tone (Control: 92±13; HF: 40±8; HF+PYR: 107±9 bpm) and reduced sympathetic tone (Control: 19±4; HF: 47±9; HF+PYR: 23±5 bpm). Cardiac function was assessed by pressure‐volume conductance catheter technique. HF rats treated with PYR exhibited higher ejection fraction (Control: 40±4; HF: 15±2; HF+PYR: 28±4%) and maximum dp/dt of left ventricular pressure (Control: 10111±523; HF: 5114±355; HF+PYR: 6437±249 mmHg/sec). However, PYR did not affect the stroke volume (Control: 98±8; HF: 41±6; HF+PYR: 62±4 μL) and the cardiac output (Control: 36±0.4; HF: 13±2; HF+PYR: 20±2 mL/min) of HF rats. In addition, PYR reduced the diameter of the myocytes (Control: 13.2±0.2; HF: 19.9±0.6; HF+PYR: 17.0±0.5 μm) and the collagen density (Control: 0.38±0.06; HF: 1.15±0.11; HF+PYR: 0.83±0.07%) of the left ventricle. In conclusion, it was demonstrated that PYR increased cardiac vagal while reduced sympathetic tone, preventing the cardiac remodeling and providing improvement of cardiac function in HF rats. Support: FAPESP, CNPq and CAPES.