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Cardiac function is diminished in diet‐induced obese mice
Author(s) -
Reddy Anilkumar K,
Hartley Craig J,
Taffet George E
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.644.28
To study the effects of obesity on cardiac function we examined left ventricular (LV) function in 12 mice (6 HFD‐high fat diet and 6 ND‐normal diet). Using a RADI pressure catheter we measured LV pressure (LVP) in mice at baseline and post‐dobutamine administration. Maximum ±dP/dt (mmHg/s), tau (msec), peak and end‐diastolic pressures (mmHg) were extracted from LVP signal. Data are presented as mean±SEM. HFD mice were significantly heavier than ND mice (51±1 vs. 28±2 g, p<0.001) but no significant differences were observed in LVP indices between them at baseline. Post‐dobutamine; HFD mice did not have different inotropic responsiveness than ND mice, but had significantly diminished relaxation; lusitropic response −dP/dtmax (−6981±1039, vs. −11690±1244 mmHg/s, p<0.02) compared to ND mice. Within group comparison showed that only +dP/dtmax was significantly higher in HFD mice post‐dobutamine compared to their baseline. However, in ND mice +dP/dtmax, −dP/dtmax, and tau were significantly enhanced post‐dobutamine compared to their baseline. These data show no differences in the baseline cardiac function of HFD and ND mice. But HFD mice neither exhibit enhanced lusitropic reserve compared to baseline values nor perform on par with their ND counterparts upon dobutamine challenge indicating perhaps a diminished cardiac lusitropic response. Supported by NIH grants HL073041 (Reddy), HL22512 (Hartley).