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Higher central and brachial artery systolic and pulse pressure in black overweight/obese adolescents: relation with aortic stiffness and pressure wave reflection
Author(s) -
Pierce Gary L,
Zhu Haidong,
StallmannJorgensen Inger,
Huang Ying,
Guo Dehuang,
Edet Itoro,
Darracott Katie,
Dong Yanbin
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.640.33
We determined if elevated central and brachial systolic blood pressure (BP) and pulse pressure (PP) in overweight/obese (OW/OB) adolescents is related to increased aortic stiffness (carotid‐femoral pulse wave velocity, CF‐PWV) or pressure wave reflection (augmentation index, AI). OW/OB (n=85; age 17.0 ± 0.2 yrs; BMI≥85%ile) black adolescents demonstrated 5–6% higher brachial and central systolic BP and 11–16% higher brachial and central PP (all P<0.01) compared with healthy‐weight (HW, n=141; age 16.8 ± 0.1 yrs; BMI <85%ile). OW/OB had 7% higher CF‐PWV (5.7 ± 0.1 vs. 5.3 ± 0.1 m/sec, P<0.01) compared with HW, but no difference in AI between groups (P>0.05). In the entire cohort (n=226) after adjusting for age, sex, heart rate, height, and mean BP, CF‐PWV was positively related to BMI%ile (r=0.22, P<0.01), waist and hip girth (r=0.17, 0.20, P<0.05), but not to central or brachial systolic BP, PP or AI. Paradoxically, AI was inversely related to brachial and central systolic BP (r=−0.35 and −0.52, both P<0.01) and PP (r=−0.29 and −0.44, both P<0.01). These data suggest that higher central and brachial systolic BP and PP in OW/OB adolescents is likely mediated by an augmented forward pressure wave amplitude from enhanced proximal aortic characteristic impedance rather than greater aortic stiffness or reflected pressure wave. Supported by NIH R01 HL077230‐02 and MCG Child Health Discovery Institute.