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Pharmacological post‐conditioning by intracoronary adenosine in a porcine model of acute myocardial infarction
Author(s) -
Hekkert Maaike te Lintel,
Tel Shanti,
Merkus Daphne,
Serruys Patrick W,
Giessen Wim J,
Duncker Dirk J
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.639.9
The most important approach to rescue jeopardized myocardium is coronary reperfusion (Rep). Mechanical or pharmacological modifications of Rep conditions potentially minimize myocardial damage. We investigated the effects of adenosine infusion during early Rep on coronary blood flow (CBF) responses, left ventricular (LV) function and infarct size. Pigs (55 kg) were subjected to 45‐min of left anterior descending (LAD) coronary artery occlusion (CAO). Adenosine (50 μg/kg/min, n=9) or saline (vehicle‐group, n=13) were infused direct into the LAD, starting 5‐min before 120‐min of Rep, after which the area‐at‐risk (AR) and infarct area (IA) were determined. CAO abolished systolic shortening (from 18±1% at baseline to ‐6±1%) leading to a decrease in stroke volume (14±2%), cardiac output (11±2%) and aortic blood pressure (13±2%). During Rep none of these parameters recovered to baseline. Adenosine infusion had no effect on either global or regional LV function compared to the vehicle group, but augmented the increase in CBF after the onset of Rep to 462±79% of baseline at 15‐min of Rep against 258±39% in vehicle treated controls. Infarct size (IA/AR) was reduced by adenosine infusion (38.0±4.9%) compared to 54.3±5.6% in the vehicle‐group. In conclusion, intracoronary adenosine infusion reduced infarct size without affecting LV function in a porcine model of acute myocardial infarction.