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Similarity in Responses Seen in Atherogenic Rabbits Treated With Soy Flour or Superoxide Dismutase
Author(s) -
Van Blaricom Amy L.,
Acosta Roberto J.,
Beard Elizabeth Letitia
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.637.4
The effects of soy flour ingestion and IP injections of superoxide dismutase bound to polyethylene glycol(SOD‐PEG 36 hr ½ life) on rabbits fed atherogenic diet(AD) for a month prior to the experiment, were studied. New Zealand strain male rabbits fed an AD of 92%Purina Rabbit Chow,6% Corn Oil, 2% Cholesterol for 4 weeks were divided into 4 groups of 5 rabbits for 4 weeks of study as follows:1.AD Control Group(ADCG) fed AD. 2.Soy Flour Group(SFG) fed AD+10% SF. 3.Saline Control Group(SCG) fed AD + injected (IP, 2/wk) with physiological saline (PS) and 4.SODPEG Group fed AD, injected (IP, 2/wk) with 2000 units of SODPEG in PS. Mean Plasminogen Activator Activity(PAA) in the ADCG plasma was 21.93% vs 25.36% in the SFG. SCG animals had mean PAA of 22.8% vs 26.1% in the SODPEG. Mean red cell SOD values (u/gm Hgb) were 1930u in the ADCG vs 3300 u in the SFG. In the SCG, SOD was 2900u vs 4100u in SODPEG. SF and SODPEG had reduced plasma cholesterol levels vs AD controls. Atherosclerotic streak development in the rabbit aortae was minimal in SFG and SODPEG compared to controls. (American Heart Association‐ Louisiana ).