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Effects of monoamine releasers varying in selectivity to release dopamine/norepinephrine versus serotonin on choice between cocaine and food in rhesus monkeys
Author(s) -
Banks Matthew L,
Blough Bruce E.,
Negus Sidney S.
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.619.9
The efficacy of monoamine releasers as candidate medications may be influenced by the relative selectivity to release dopamine/norepinephrine versus serotonin. The aim was to assess the effects of 7‐day treatment with m ‐fluoroamphetamine, methamphetamine, phenmetrazine and fenfluramine that vary from most dopamine‐selective to most serotonin‐selective on the relative reinforcing strength of cocaine using a cocaine versus food choice procedure in rhesus monkeys (n=4). Cocaine choice curves and ED50 values were determined under baseline and test conditions during which a dose of the test drug was continuously administered for 7 days. Under baseline conditions, food was chosen during availability of low cocaine doses, and cocaine was chosen during availability of higher cocaine doses. Treatment with m ‐fluoroamphetamine reduced cocaine choice and increased food choice in all monkeys and produced a significant rightward shift in the cocaine choice curve. Treatment with methamphetamine and phenmetrazine also produced rightward shifts in the cocaine choice curve, but the results were more variable across monkeys. Treatment with fenfluramine produced non‐significant leftward shifts in the cocaine choice curve. These results support the potential of dopamine‐selective releasers as candidate pharmacotherapies for cocaine dependence. This work was funded by NIH grant R01‐DA26946.