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Antinociceptive activity of carvacrol in formalin‐, capsaicin‐ and glutamate‐induced orofacial nociception in rodents
Author(s) -
Júnior Lucindo José Quintans,
Guimarães Adriana Gibara,
Oliveira Makson G.B.,
Barreto Rosana Siqueira,
Cavalcanti Sócrates C.H.,
Araújo Adriano A.S.,
Santos Márcio R.V.,
Quintans Jullyana S.S.,
Bonjardim Leonardo R.
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.617.8
Subject(s) - nociception , capsaicin , orofacial pain , carvacrol , pharmacology , chemistry , anesthesia , medicine , receptor , chromatography , surgery , essential oil
To evaluate the antinociceptive effect of carvacrol (CARV), a monoterpene phenol, in formalin‐, capsaicin‐ and glutamate‐induced orofacial nociception on mice. Male mice were pretreated with CARV (25, 50 and 100 mg/kg, i.p.), morphine (5 mg/kg, i.p.) or vehicle (distilled water + one drop of Tween 80 0.2%), before formalin (20 μl, 2%), capsaicin (20 μl, 2.5 μg) or glutamate (40 ìl, 25 ìM) injection into the right upper lip. Experimental protocols were approved by the Animal Care and Use Committee at the Federal University of Sergipe. Our results revealed that i.p. pretreatment with CARV was effective in reducing nociceptive face‐rubbing behaviour in both phases on formalin test and also produced significant antinociceptive effect at all doses in the capsaicin‐ and glutamate‐ tests. Such results were unlikely to be provoked by motor abnormality. Results suggest that CARV might represent important tool for treatment of orofacial pain. Financial Support: FAPITEC/SE and CNPQ (Brazil).