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Histopathological effects of ortanique peel polymethoxylated flavones on organ structures of hypercholesterolemic rats
Author(s) -
Green Curtis Omar,
Wheatley Andrew O,
Hanchard Barrie,
Gibson Tracey,
McGrowder Donovan A,
dilworth Lowell L,
Asemota Helen N
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.616.2
The aim of this study was to evaluate the histopathological effects of Ortanique peel polymethoxylated flavones extract (PMFort) on the organ structures of diet‐induced hypercholesterolemic rats. Adult Sprague‐Dawley rats were fed normal rat chow as well as high cholesterol diets supplemented with PMFort. The liver, kidney and bowel of hypercholesterolemic rats fed PMFort were evaluated using a light microscope to determine possible morphologic alterations, compared to untreated hypercholesterolemic rats and normal rats fed rat chow. Untreated hypercholesterolemic rats showed significantly altered intestinal morphology, with an increase in the number of absorptive cells and in villus length when compared to untreated normal rats. They also exhibited hepatic steatosis and inflammation. Hypercholesterolemic rats treated with PMFort showed reductions in absorptive cell number, villus length and hepatic steatosis compared to the untreated hypercholesterolemic rats. The current results would suggest that PMFort consumption has no toxic effects on the organs of hypercholesterolemic rats but may ameliorate hypercholesterolemia‐associated alterations in organ structures.