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Placental heme oxygenase‐2 expression in pregnant adolescents is related to placental iron content and FLVCR expression
Author(s) -
Bemis Thomas,
Foehr Marisa,
Jaacks Lindsay,
McNanley Thomas J,
Cooper Elizabeth M,
Pressman Eva K,
McIntrye Allison W,
Abkowitz Janis L,
Guillet Ronnie,
O'Brien Kimberly O
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.607.13
Heme oxygenase‐2 (HO‐2) functions in part to catabolize intracellular heme. This enzyme is present in the human placenta but its potential relationship to iron (Fe) status remains poorly described. Placental HO‐2 and Fe status were measured in term placental tissue obtained from 54 pregnant adolescents (age 17.6 ± 1.1 y). Placental expression of HO‐2 and the heme transporter, Feline Leukemia Receptor Virus subclass C Receptor (FLVCR), were measured by western blot. Serum ferritin (SF) and transferrin receptor (sTfR) were measured at mid‐gestation (25.1 ± 3.5 wks) and in maternal/cord blood at delivery (39.8 ± 1.1 wks). Of the teens studied, 12/43 of teens were anemic at delivery (Hb<11), 20/48 had depleted Fe stores (SF<20 ug/L), and 6/43 had tissue Fe deficiency (sTFR>8.5ug/L). Placental Fe content averaged 300.5 ± 105.8 ug Fe/g tissue and neonatal SF averaged 124.5 ± 57.9 ug/L. Placental Fe content was not correlated to maternal or neonatal iron status indicators. HO‐2 expression was positively correlated with placental Fe content (p<0.003, n=40) but was not significantly associated with other maternal or neonatal Fe status indicators. Placental HO‐2 expression was significantly associated with placental FLVCR expression (p<0.002, n=38) which may suggest that HO‐2 plays a role in placental Fe utilization. USDA: 2005‐35200 and 2008‐0857