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Eating competence is related to PPARβ/δ and PGC‐1α genotypes
Author(s) -
Lohse Barbara A,
Heuvel Jack Vanden,
Krall Jodi Stotts,
Patterson Jill,
Kattelmann Kendra,
White Adrienne A,
Greene Geoffrey
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.605.2
Subject(s) - genotype , medicine , competence (human resources) , endocrinology , gastroenterology , psychology , biology , genetics , gene , social psychology
The Three Factor Eating Questionnaire (TFEQ) has demonstrated genetic variation and association with Satter Eating Competence Inventory (ecSI) scores. We studied college students (n=661, 36% male, 91.5% non‐Hispanic white, 26% overwt/obese) to identify genotype and eating competence (EC) relationships. PPARα L162A, PPARγ 12A, PPARβ/δ rs226766 , and PGC‐1α G482S genotype distributions were compared with TFEQ‐R18 and ecSI scores; responses were gender‐specific and paralleled published values. Results confirmed less emotional eating (EE) (P<.001), cognitive restraint (CR) (P<.001) and uncontrolled eating (UE) (P=.1) with EC (ecSI score ≥ 32). Subjects in the lowest ecSI tertile had significantly more CR (P<.001), EE (P<.001), and UE (P=.007). The homozygous G/G PPARβ/δ genotype tended (P=.06) toward less UE; females with the homozygous G/G PPARβ/δ genotype tended (P=.1) toward less CR than males. Homozygous A/A PPARγ genotype tended (P=.08) toward less CR and significantly more UE (P=.04). Students of homozygous S/S PGC‐1α genotype (n=35) tended not to be eating competent (P=.05) and to be in the lowest ecSI tertile (P=.14). The PPARβ/δ genotype and gender interaction was significant (P=.04) with higher ecSI scores for males (35.3 ± 5.8 vs. 30.8± 4.9) who were homozygous G/G. These data support the hypothesis of a link between EC and PPARβ/δ and PGC‐1α genotypes. Funded by NRI, USDA #2005‐35215‐154121541.