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Vitamin D insufficiency limits bone mineral adequacy in Brazilian adolescent boys
Author(s) -
Moura Bárbara F,
Normando Paula,
Costa Amina C.,
Bezerra Flávia F.
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.603.15
The aim of this study was to evaluate vitamin D status and investigate its association with bone density adequacy for age of 46 Brazilian adolescent boys (10–14 y, tanner stages 2–4) consuming low calcium diets (mean 514mg/d). Serum 25OHD and iPTH were measured by chemiluminescence immunoassay. Total body mineral content (TBMC), total body (TBMD) and femur (FBMD) bone mineral density were assessed by DXA. Serum 25(OH)D was on average 45.4nmol/L and was influenced by month of sample obtention, being lower between may/september compared to december/march (36 ± 15 vs 63±25 nmol/L, respectively, P<0.001). Serum 25(OH)D correlated negatively with iPTH (r= −0.31, P<0.05) and positively with TBMD Z scores (r= 0.38, P<0.01) and FBMD Z scores (r= 0.45, P<0.01). Correlations with bone measurements remained significant after controlling for month of sample obtention. 25(OH)D was also identified as a factor influencing TBMD (P<0.001) and FBMD Z (P<0.01) scores in a stepwise multiple regression analysis that included age, tanner stage, height, weight, calcium intake, month of sample obtention and PTH. Our results suggest that vitamin D insufficiency may be common among Brazilian adolescents and that 25OHD concentrations are also susceptible to seasonal variation in Brazil. Moreover, these results suggest that bone mass may benefit from improving vitamin D status in adolescent boys. Financial support: Faperj (Brazil).