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EFFICACY OF LOWAT ‐ A NATURAL WEIGHT MANAGEMENT HERBAL FORMULATION IN OBESE HUMAN SUBJECTS
Author(s) -
Bagchi Debasis,
Lau Francis C,
Golakoti Trimurtulu,
Krishnaraju Alluru V,
Sengupta Krishanu
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.601.10
We investigated the efficacy and safety of LOWAT a novel herbal weight management formula comprising of extracts Piper betle and Dolichos biflorus . In a randomized, double‐blind, placebo‐controlled study, subjects (n=25) received 900 mg/day of LOWAT for 8 weeks and maintained a standard 2000 calorie daily diet. Body weight, BMI, clinical chemistry and hematological parameters, urine analysis and biochemical markers: adiponectin and ghrelin were measured at baseline and weeks 2, 4 and 8 of treatment. After week 2, subjects lost 1.41 kg of their mean body weight compared to 0.79 kg reduction in placebo group while BMI reduction was 0.534 kg/m 2 compared to placebo (0.309 kg/m 2 ). After week 8, LOWAT group exhibited a significant 2.4 fold (140%) body weight reduction (p<0.05). BMI was reduced by 2.4 fold (136%) compared to placebo (p<0.05). Serum adiponectin significantly increased 15.3% (p<0.05) and serum ghrelin significantly decreased by 17.3% (p<0.05) compared to placebo. These results are further substantiated by an in vivo study in which LOWAT significantly reduced body weight gain and increased serum adiponectin level in rats on a high fat diet as compared to control. Minor adverse events reported by subjects were not treatment related. The safety of LOWAT was further established by a series of acute and sub‐acute toxicity studies in animals. This study further proves the efficacy of LOWAT in reducing body weight and BMI and improving key biochemical parameters of obesity in obese subjects.