PTX 3 concentration in relation to malnutrition – inflammation syndrome in HD patients

Cardiovascular (CVS) morbidity and mortality in the dialysis patients is 10–30 folds higher than in general population. There are specific CVS risk factors for dialysis patients which are components of malnutrition‐inflammation syndrome. The pentraxin 3 (PTX 3) is mediator of inflammation, connected with increase risk of atherosclerosis and cardiovascular disease in dialysis patients. It is very important to establish all CVS risk factors in the HD patients to prevent CVS diseases and mortality in this population. The aim of the study was to determine concentration of PTX 3 and its relation with markers of chronic inflammation and nutritional status in hemodialysis (HD) patients. Methods The study was performed in 34 HD patients and in the control group consisted of 33 healthy volunteers. The nutritional status was determinated by a Subjective Global Assessment (SGA) method, albumin concentration and anthropometric measurements. C‐reactive protein was measured as markers of inflammatory status. Concentrations of PTX 3 was measured by ELISA method. Results PTX 3 and CRP levels were significantly higher in HD patients than in controls (p< 0.001). The malnutrition (SGA <5 points) were observed in 51.4% of HD patients. The malnutrition inflammation syndrome was recognized in 20.5% of patients. The level of PTX 3 was not correlated with nutritional status and also with CRP. The concentration of PTX 3 was significantly higher in diabetic HD patients in comparison to non‐diabetic (p<0.01). Conclusion High concentration of PTX 3 in diabetic HD patients suggests evaluated risk for CVS in this group of patients.