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Plasma micronutrient concentrations are associated with inflammatory cytokine levels among Mexican women with greater abdominal fat and higher leptin levels
Author(s) -
Long Kurt Zane,
Garcia Olga P,
Zavala Gerardo,
Carmen Caamano Maria,
Salgado Luis M,
Rosado Jorge L
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.595.12
Associations between micronutrient status and inflammatory cytokine responses were evaluated in a cross‐sectional study of 580 women from rural Mexico who differed in abdominal fat mass (AFM) and leptin levels. Women's AFM (%) was determined using DEXA. Concentrations of IL‐6, TNF‐α, leptin, Zn, vitamins A, C, and E were determined in fasting blood samples. Ordered logistic regression models evaluated associations between categorized cytokine levels and micronutrients concentrations stratified by quartiles of abdominal fat and leptin. Higher plasma Zn was associated with reduced IL‐6 levels among women in the 3 rd quartile of AFM (OR=0.21, 95% CI 0.08–0.6, P=0.03) and reduced TNF‐α levels among women in the 4 th quartile (OR=0.30, 95%CI 0.11–0.76, p=0.02). Higher vitamin E concentrations were associated with increased IL‐6 and TNF‐α levels among women in the 4 th AFM quartile (OR=1.43, 95% CI 1.06–1.93, p=0.01; OR=1.71, 95%CI 1.16–2.55, p<0.01, respectively). Higher Zn and vitamin E concentration were associated with reduced and increased IL‐6 levels among women with intermediate levels of leptin (OR=0.25, 95% CI 0.1–0.64, p<0.01; OR=1.23, 95% CI 0.99–1.53, p=0.05, respectively). No associations were found among women in the lowest quartiles of AFM or leptin. Contrasting associations between Zn and vitamin E status with inflammatory cytokines are present among women with greater AFM and higher leptin levels.