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Effect of green tea polyphenols and Tai Chi exercise on bone health in postmenopausal women with low bone mass: a 24‐week placebo‐controlled randomized trial
Author(s) -
Shen ChwanLi,
Chyu MingChien,
Yeh James K,
Zhang Yan,
Pence Barbara C,
Felton Carol K,
Brismee JeanMichel,
Dagda Raul Y,
Doctolero Susan,
Flores Mary J,
Wang JiaSheng
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.594.3
Subject(s) - medicine , bone health , osteoporosis , postmenopausal women , placebo , randomized controlled trial , physical therapy , green tea , bone mass , alternative medicine , bone mineral , food science , chemistry , pathology
Osteoporosis is a major health problem in postmenopausal women. This study evaluated the effects of green tea polyphenols (GTP) supplementation and Tai Chi exercise (TC) on bone health and related mechanism in postmenopausal osteopenic women. 171 postmenopausal osteopenic women were assigned to 4 groups: placebo, GTP, placebo+TC, and GTP+TC for 24 weeks. Overnight fasting blood and urine were collected at baseline, 4, 12, and 24 weeks for bioavailability, bone turnover biomarkers (bone‐specific alkaline phosphatase, BAP; tartrate resistant acid phosphatase, TRAP), and oxidative stress damage (8‐OHdG). Muscle strength was evaluated by wall‐sit test at baseline, 12, and 24 weeks. Data were analyzed statistically. After 24 weeks, 150 women completed the study. The levels of urinary epicatechin and epigallocatechin as well as that of serum epigallocatechin and epigallocatechin gallate were significantly higher in GTP‐supplemented groups than placebo groups. GTP supplementation increased BAP levels after 4 weeks, while TC exercise increased BAP levels after 12 weeks. Neither GTP nor TC affected serum TRAP levels. The GTP, placebo+TC, and GTP+TC groups suppressed 8‐OHdG but improved muscle strength after 24 weeks. Our data demonstrated that GTP supplementation and TC exercise benefited bone remodeling and muscle strength in postmenopausal osteopenic women through a reduction of oxidative stress damage.