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Supplementation of Human Milk with Calcium, Phosphorus, and Post‐Discharge Formula
Author(s) -
Fogleman April Danielle,
Sakamoto Pauline,
Cohen Ronald S.,
Allen Jonathan C.
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.589.2
Premature infants at risk for metabolic bone disease may need increased minerals for normal bone mineralization, in which case supplementation of human milk (HM) with calcium (Ca) and phosphorus (P) is common. The bioavailability of these additives has not been proven. Objectives were to study the effect of Ca, P, and post‐discharge formula (PDF) supplementation on protein (PRO), free fatty acids (FFA), and Ca in donor HM. An in‐vitro model of the premature infant's gastrointestinal tract was developed to simulate digestion and absorption. PRO, FFA, free Ca, and total Ca were measured before and after in‐vitro digestion in HM with and without added supplements. Donor HM loses CO2 during processing. Adding supplemental Ca increases free Ca in donor HM and does not interfere with PRO and fat digestion. The amount of Ca absorbed from donor HM supplemented with PDF is not significantly different from Ca absorbed from milk alone. Supplemental Ca and P added together increases the total amount of Ca absorbed in‐vitro, despite causing an increase in insoluble Ca. Supplementing HM with Ca, P, and PDF does not have a negative impact on HM. Ca absorbed in‐vitro from PDF is not significantly different from Ca absorbed from HM alone. Combined Ca and P supplementation makes a soluble complex with good in‐vitro absorption that can then dissociate to allow Ca to bind to albumin. Grant Funding Source : Mothers' Milk Bank, San Jose, CA