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Reliability Characteristics of Continuous Glucose Monitoring in Overweight and Obese Men and Women with Type 2 Diabetes Mellitus
Author(s) -
Maki Kevin C,
Rubin Kristin Herron,
Matusheski Nathan V,
Rubin Martyn R,
Reeves Matthew S,
Lawless Andrea,
Kaden Valerie N,
Black Richard M
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.587.7
Continuous glucose monitoring (CGM) can be useful in clinical settings as well as in research to evaluate interventions aimed at altering glycemic control. The purpose of this study was to evaluate the reliability characteristics of glucose data obtained by CGM during two 5‐day periods in subjects with type 2 diabetes mellitus. Subjects were men (n=14) and women (n=32) taking oral hypoglycemic medications, but no injectable medications. CGM sensors (DexCom SevenPlus®, DexCom, Inc.) were inserted subcutaneously and worn for two consecutive 5‐day periods (Period 1 and 2). The glucose values were not visible to subjects other than during calibration. At the completion of each 5‐day Period, the CGM sensor was removed and the glucose data downloaded. Subjects had a mean (±standard deviation) age of 59.9±10.5 yr, body mass index of 33.0±4.9 kg/m2, fasting glucose of 137.6±34.4 mg/dL, and HbA1C of 6.8±0.8%. Mean 24‐hour interstitial glucose measured for Period 1 (146.5±32.6 mg/dL) and Period 2 (142.2±28.3 mg/dL) were not significantly different (−4.3±17.0 mg/dL, p=0.092). Interstitial glucose readings from Period 1 and Period 2 were significantly positively correlated (r=0.85, p<0.0001). The coefficient of variation of the method error was 24.0%. Mean interstitial glucose values using this CGM device had sufficient repeatability for use in moderately sized clinical trials.