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Assessing the long term effects of dietary starch, glucose and fructose in pigs: Effects on glucose tolerance and growth
Author(s) -
Cline Paul M,
Dove C.R.,
Tsai T.,
Azain M.J.
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.587.2
The objective of this study was to measure growth, intake and the metabolic responses to feeding purified monosaccharides to growing pigs over a 9 wk period. Rodent studies show increased de novo lipogenesis and decreased insulin sensitivity in response to fructose, but it is unclear if these effects occur in the same progression in humans. The use of pigs as a model for humans is more appropriate as they have similar GIT physiology. A total of 24 pigs were assigned to one of four diets: 20% starch, 10% glucose, 10% fructose, or 20% fructose. During the study, pigs grew from 28 kg to 80 kg, which represents adolescent growth in humans. Body weight, intake and body composition (ultrasound) were not affected by diet. IVGTT and response to meal tests were completed at the end of 9 wks. Blood was analyzed for glucose, fructose, insulin, leptin, TG, and cholesterol concentrations. There was a significant difference in K values due to diet with high fructose being the most insulin sensitive and low fructose being the least (P<0.05). The results from this study demonstrate pigs can be used as a viable model to test long‐term effects of feeding various carbohydrates on blood metabolites and body composition.