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Dietary Fatty Acid Composition Influences Levels of Fatty Acid Ethanolamides but not Energetics in Syrian Golden Hamsters
Author(s) -
Lin Lin,
Ridout Todd,
Harding Scott V,
Yang Haifeng,
Jones Peter JH
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.585.12
Dietary fatty acids (DFAs) can be converted to fatty acid ethanolamides (FAEs), such as oleoylethanolamide (OEA), palmitoylethanolamide (PEA) and arachidonoylethanolamide (AEA), associated with lipid signalling, fat oxidation and appetite control. However, how FAEs respond to variation in DFAs remains poorly understood. Our objective was to identify the impact of diets containing canola (CA‐O), fish (FO), corn (CO) or docosahexaenoic acid‐canola mixture (DHA‐C) on plasma and organ levels of OEA, PEA and AEA (OPA‐EA) and energy metabolism in hamsters. Sixty hamsters were provided diets containing 6% treatment oil for 30d. Growth rates, food intake, body fat and O 2 consumption did not differ across groups. FO reduced lean body mass compared to CO (p<0.05) but not other diets. Plasma OEA and PEA levels were higher in FO (p<0.05) compared to all other groups. Intestinal OEA levels were higher in CA‐O and DHA‐O compared to CO (p<0.05), but not FO. Hepatic and intestinal PEA levels did not differ between groups. CO plasma and liver AEA levels were higher than FO and DHA‐O (p<0.01), but not CA‐O groups. In all groups OPA‐EA levels in intestine were >20X higher than in plasma and 1.5X higher than in liver. To conclude, although varying DFAs produced marked shifts in plasma and organ levels of OPA‐EA, these changes did not translate into discernable changes in energy balance or body composition. Supported by NSERC Grant Funding Source : NSERC