Premium
Feeding resistant starch (RS) to Goto‐Kakizaki (GK) diabetic rats improves pancreatic beta cell mass of dams and fasting glucose of offspring
Author(s) -
Shen Li,
Keenan Michael J.,
Raggio Anne M.,
Zhou June,
Williams Cathleen C.,
Martin Roy J.
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.584.11
Dietary prebiotics show potential in anti‐diabetes. Dietary RS has afavorable impact on gut hormone profiles, including GLP‐1 consistently released, a potent anti‐diabetic incretin(Zhou et al, 2008). Also RS reduced body fat and improved glucose tolerance in rats and mice (Keenan, 2006; Zhou, 2009). In the current project, we hypothesize that dietary resistant starch can improve insulin sensitivity and pancreatic beta cell mass in a type 2 diabetic rat model. Altered gut fermentation and microbiota are the initial mechanisms, and enhancement in serum GLP‐1 is the secondary mechanism. The GK rat is a non‐obeseWistar sub‐strain, which develops Type 2 diabetes mellitus early in life. In this study, GK rats were fed a RS diet with 30% RS and an energy control diet. After 10 weeks, these rats were mated and went through pregnancy and lactation. At the end of the study, pancreatic beta cell mass, insulin sensitivity, pancreatic insulin content, total GLP‐1 levels, cecal short chain fatty acid concentrations and butyrate producing bacteria in cecal contents were greatly improved by RS feeding. The offspring of RS fed dams showed improved fasting glucose levels and normal growth curves. This dietary approach is potentially of great therapeutic importance in the treatment of diabetes and improvement in outcomes of pregnancy complicated by diabetes. Funding: National Starch; LSU AgCenter.