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Fermented Korean red ginseng inhibits the development of oxazolone‐induced atopic dermatitis conditions in hairless mice
Author(s) -
Kim MiJung,
Ji GeunEog,
Sung MiKyung
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.583.16
Atopic dermatitis (AD) is characterized by chronic inflammation of the skin. This study was performed to investigate the efficacy of fermented Korean red ginseng (FRG) supplementation on the severity of AD conditions in hairless (SKH1) mice treated with oxazolone (OX). Four groups of animals were fed either 0.1% or 0.3% FRG diet starting either before or after OX treatment. Animals were sacrificed at wk 13 of the experimental period. Results indicated that FRG at both concentrations inhibited the development of the AD skin lesions, as evidenced by decreases in scratching behaviors and reduced inflammation. Efficacy was confirmed by decreased circulating concentration of macrophage‐derived chemokine, thymus activation‐related chemokine, eotaxin and relative mRNA expression levels of IL‐4 and IFN‐¥ã in the dorsal skin most significantly in animals fed FRGD before and after OX treatment. These results suggest that FRG suppresses the development of AD skin lesions, possibly by reducing mast cell infiltration and Th2 cell‐mediated immune responses. This study was supported by a grant of the Korea Healthcare Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (A090001).