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Comparative Study of Dried Fruits and Their Ability to Restore Bone Microarchitecture in Osteopenic C57BL/6 Mice
Author(s) -
Smith Brenda Jane,
Hembree Kelsey,
Rendina Elizabeth,
Wang Yan,
Marlow Denver,
Clarke Stephen L.,
Halloran Bernard P.,
Lucas Edralin A.
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.581.18
Subject(s) - microarchitecture , computer science , embedded system
Efforts to develop new strategies for the prevention and treatment of osteoporosis have resulted in the evaluation of numerous functional foods and their bioactive components. Dietary supplementation with dried plum restores bone lost due to aging and ovarian hormone deficiency, but the extent to which these effects are unique to dried plum is unclear. Twelve‐wk‐old female C57BL/6 mice were sham‐operated or ovariectomized (OVX) and maintained on the control diet (AIN‐93M) for 2 wks to induce osteopenia. Subsequently, dietary treatments were initiated for 8 wks: control diet or control diet + 25% dried plum, apple, apricot, grape or mango. Vertebral bone microarchitecture was assessed using micro‐CT (SCANCO Medical). Mice receiving the dried plum and apricot diets increased (P<0.05) trabecular bone volume (BV/TV) compared to the OVX group, but only the dried plum group restored BV/TV to that of the sham cohort. Likewise, dried plum was the only treatment that restored trabecular number (Tb.N) and separation (Tb.Sp) to the sham. Trabecular bone connectivity and structural model index were improved (P<0.05) with dried plum treatment. These data indicate that dried plum has unique effects on bone compared to the other dried fruits investigated. Mechanistic studies are underway to determine the influence of this dried fruit and its bioactive components on bone metabolism.