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Expression of Hypoxia inducible factor mRNA in human gingival tissue
Author(s) -
sato iwao,
Miwa Yoko,
Shimada Kazuyuki
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.491.4
Objectives Vascular endothelial growth factor (VEGF) is a key regulator of blood vessel endothelium. The angiogenesis marker is unknown between vascular growth factors and hypoxia‐inducible factor in human gingival tissue associated with periodontal probing depth. Methods We examined blood supply and localization of VEGF, type III tyrosine kinase receptors (VEGF‐R2), and Hypoxia inducible factor (HIF) markers in immunohistochemical levels in two groups (normal (<3 mm) and inflammation (3 mm<)) with gingival sulcular depth groups) and expression of VEGF, VEGF‐R2 Lymphatic Vessel Endothelial Receptor 1(LYVE‐1), Cysteine‐aspartic‐acid‐protease (Caspase‐3) and HIF mRNA from small quantity of biopsy of samples in human gingival tissue. Results The large blood was scattered in surface region of the gingival tissue in inflammation group. The level of mRNA VEGF‐R2 and HIF were high in gingival tissue of normal group in contrast to VEGF with high level in inflammation group. Conclusions Different levels of mRNA of VEGF‐R2 and HIF may reflect the functional property of blood supply via capillary and collecting blood by the changes in gingival sulcular depth. We also thought that HIF reflect to the periodontal early disease in gingival tissues.