Premium
Voluntary exercise, spontaneous physical activity, and systemic skeletal robusticity in high endurance‐running mice
Author(s) -
Copes Lynn Erin,
Schutz Heidi,
Dlugsoz Elizabeth M.,
Garland Theodore
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.488.7
Subject(s) - anatomy , femur , skeletal muscle , sed , biology , medicine , surgery
To explore the effect voluntary exercise on a wheel and spontaneous physical activity (SPA) in cages on skeletal robusticity, we housed 50 female mice from lines that had been artificially selected for high running (HR lines) and 50 mice from non‐selected control (C) lines in cages with or without wheels. Wheel running and SPA (passive infrared sensors) were monitored during each 1‐minute interval. The experiment began when the mice were 24–27 days of age and lasted 12 weeks. After sacrifice, the mice were skeletonized and their interparietal bone, along with right parietal, humerus, and femur μCT scanned. Mean, median, and maximum total thickness of the parietal and interparietal bones was determined. Geometric cross‐sectional measures of strength were determined for the long bones. No measure of activity (duration or intensity of either wheel running or SPA) was a significant predictor of cranial vault thickness (CVT) within any group. Mice with wheels did not show increased CVT or postcranial robusticity compared to unexercised animals. However, the HR lines were more postcranially robust than the C lines whether provided with wheels or not. This indicates that selection over many generations has a larger affect on skeletal robusticity than 3 months of exercise in an individual's lifetime. Funding for this project provided by an NSF DDIG 0925793 to LC and IOB‐0543429 to TG. Grant Funding Source: NSF