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Serum miRNAs as Biomarkers of Blast–induced Neurotrauma
Author(s) -
Balakathiresan Nagaraja Sethuraman,
Bhomia Manish,
Chavko Mikulas,
McCarron Richard M,
Maheshwari Radha,
Maheshwari Radha
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.441.8
Traumatic brain injury (TBI) arising from blast exposure during the war is the predominant cause of neurotrauma in military populations. Cellular, molecular, and biochemical including neuropathology changes occur in TBI following blast exposure. MicroRNAs (miRNAs) are important regulators of many biological, cellular and physiological functions. Circulating miRNAs present in serum/plasma are characteristically altered in many pathological conditions, and have been employed as diagnostic markers for specific diseases. In the present study, the miRNA expression profile in serum after three repeated moderate blast exposure (120 kPa) in rats at various time points showed that 34 miRNAs significantly altered, Pathway analysis of these miRNAs revealed that six miRNAs let‐7e, 30d, 148b, 122a, 298 and 352 are involved in brain related functions. Among them, miRNAs 298 and 352 directly inhibits protein‐tyrosin kinase oncogene family which is required in brain development and function and over expression of UCK 2 in Huntington's diseases and serve as Biomarker, respectively. Mir 122 indirectly inhibits the H 2 O 2 which has a role on neuromodulatory functions in the brain. These results demonstrate that circulating miRNA levels are altered after blast TBI and may provide a rich new source of potential molecular biomarkers. These studies are supported by a grant from Defense Medical Research Development Program.