Correlation of Morphology, Cytogenetics, and High‐Resolution Genomic Profiling in a Group of Benign and Atypical Meningiomas

Meningiomas are tumors with numerous subtypes and three WHO‐grades, ranging from benign to atypical and anaplastic. Radiological and morphological criteria including the proliferation index are decisive for classification and prognosis. Genetic studies of a number of characteristic changes such as those on chromosome 22 have been predominantly of concern in familial cases. We have analyzed genomic aberrations of 10 benign and atypical sporadic meningiomas together with the corresponding blood samples, using SNP‐arrays combined with GTG‐banding, spectral karyotyping, and locus‐specific FISH. Loss and gain of chromosome 22q was found in several meningotheliomatous tumors of both grades, as was the paracentric inversion within 1p36 that was previously described by us in a case of multiple meningiomas. We detected a novel balanced reciprocal translocation t(4;10)(q12;q26) in a benign meningioma. Copy neutral LOH indicating uniparental disomy (UPD) were de novo found in regions 4p16.1, 7q31.2, 8p23.2, and 9p22.1 in primary meningioma cells. A de novo gain 19p was exclusively present in an atypical meningioma with chordoid formations. The possible significance of these genetic changes needs to be validated in larger patient series.