Mechanisms of cardiac regeneration in zebrafish

By contrast with mammals, teleost zebrafish regenerate cardiac muscle after major injury. Following resection of the apex of the zebrafish ventricle, cardiomyocyte hyperplasia renews myocardium and restricts scar formation. Here, we have used new models of cardiac injury to probe the regenerative capacity of zebrafish myocardium, and we are dissecting the injury responses of non‐myocardial tissues that facilitate this capacity. Our studies reveal a new dimension of regenerative capacity by adult zebrafish heart that is amenable to cellular and molecular dissection.