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Associations of serum vitamin A and carotenoid levels with markers of prostate cancer progression among US men
Author(s) -
Beydoun Hind A,
Shroff Monal,
Mohan Ravinder,
Beydoun May A
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.344.6
We evaluated associations of serum vitamin A and carotenoid levels with markers of prostate cancer progression among 3927 US men, 40–85 years of age, who participated in the 2001–2006 National Health and Nutrition Examination Surveys. Five recommended definitions of prostate cancer progression were adopted using total and free prostate specific antigen (tPSA and fPSA) laboratory measurements. Men were identified as high‐risk based on alternative cut‐offs, namely, tPSA>10 ng/ml, tPSA>4 ng/ml, tPSA> 2.5 ng/ml, %fPSA<25% and %fPSA<15%. %fPSA was defined as (fPSA÷tPSA)x100%. Serum levels of vitamin A (retinol, retinyl esters) and carotenoids (α‐carotene, β‐carotene, β‐cryptoxanthin, lutein+zeaxanthin, lycopene) were defined as quartiles and examined as risk/protective factors for PSA markers. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using binary logistic models. After adjustment for known demographic, socioeconomic and lifestyle confounders, high serum levels of retinyl esters (tPSA>10 ng/ml: Q4vs.Q1→OR=0.38, 95% CI: 0.14–1.00) and α‐carotene (%fPSA<15%: Q4vs.Q1→OR=0.49, 95% CI: 0.32–0.76) were found to be protective whereas high serum level of lycopene (tPSA>2.5 ng/ml: Q4vs.Q1→OR=1.49, 95% CI: 1.01–2.14) was identified as a risk factor for prostate cancer progression. Monitoring specific antioxidant levels may be helpful in preventing prostate cancer progression.