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Potential effects of lignan‐enriched flax seed powder on blood pressure, fat accumulation, and lipid profile in rats
Author(s) -
Park Jae B,
Velasquez Manuel T.
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.339.6
Subject(s) - adipose tissue , chemistry , endocrinology , medicine , leptin , blood lipids , lignan , adipose capsule of kidney , fructose , high density lipoprotein , lipid profile , blood pressure , cholesterol , food science , obesity , biochemistry , biology , kidney , stereochemistry
The potential effects of lignan‐enriched flax seed powder on blood pressure, visceral fat accumulation, and lipid profiles were investigated in vivo using Sprague‐Dawley rats fed a high‐fat and high‐fructose diet. The rats were divided into three groups (n=10); a normal control diet (NC), a high‐fat and high‐fructose diet (HFD), and a high‐fat and high‐fructose diet with 0.2% LFP (HFDFlax). The experiment was conducted for 12 weeks to monitor water and feed intake, blood pressure, and body weight. Adipose tissue weight, serum total cholesterol (Total‐C), triacylglycerol (TG), high density lipoprotein cholesterol (HDL‐C), low‐density lipoprotein cholesterol (LDL‐C), and leptin levels, hepatic Total‐C and TG levels were determined. In addition, changes in liver and epididymal adipose tissues were determined. Feed intakes among the experimental groups were not significantly different, but body weight gain and blood pressure were considerably lowered in the HFDFlax group compared with the HFD group (P<0.05). Analysis of serum lipid profiles and the relative weights of epididymal and perirenal adipose tissues suggested differences between the three groups. This study was funded by USDA project number 1235‐51000‐054‐00D.