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Hyperleptinemia, adiposity and risk of metabolic syndrome in older adults
Author(s) -
Mishra Suruchi,
Sahyoun Nadine,
Mehta Mira,
Hue Trisha F,
Miljkovic Iva,
Satterfield Suzanne,
De Rekeneire Nathalie,
Harris Tamara B
Publication year - 2011
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.25.1_supplement.332.5
To examine the prospective association between serum leptin and the risk of metabolic syndrome in relation to measures of body adiposity and proinflammatory cytokines, we used data from the Health, Aging and Body Composition Study of well‐functioning older adults aged 70 to 79 years in 1997–98 and 2002–03. Variables of body adiposity and systemic inflammation were assessed in detail. Among women, serum leptin quintile 2 (p=.008), 3 (p=.009), 4 (p=.0002), and 5 (p<.0001) were significantly associated with the risk of developing metabolic syndrome at year 6 follow up as compared to quintile 1 after adjusting for potential confounders (age, gender, race, study site, education, smoking status, alcohol use, physical activity, and calorie intake) among women. This association remained significant after further adjustment for fat depots (p=.0024) and proinflammatory cytokines (p=.0098). Among men, association between serum leptin and risk of metabolic syndrome was not independent of body adiposity. Among women, elevated concentrations of serum leptin may increase the risk of developing metabolic syndrome independent of body adiposity and proinflammatory cytokines. Supported by NIA/NIH. Grant Funding Source : American Society for Nutrition